%0 Journal Article
%T PHOSPHATIDYLCHOLINE CONTAINING LONG CHAIN OMEGA-3 FATTY ACIDS: A TREATMENT ADJUNCT FOR PATIENTS WITH ANOREXIA NERVOSA?
%A Dalton
%A Bethan
%A Himmerich
%A Hubertus
%A J. Field
%A Catherine
%A Mavrogiannidis
%A Theodoros
%A Patsalos
%A Olivia
%J -
%D 2020
%R 10.24869/psyd.2020.55
%X Sa£¿etak Background: Anorexia nervosa (AN) is a serious mental disorder with a high mortality rate and often a chronic course. In contrast to many other common mental disorders, there is no drug therapy approved for AN. Methods: We performed a narrative literature review to consider whether a choline-containing molecule, such as phosphatidylcholine (PC), with an omega (¦Ø)-3 long chain polyunsaturated fatty acid (LCPUFA) could be a potential future medicinal treatment for AN. Results: Choline and LCPUFAs have individually shown benefit for mental health. Case series and pilot studies suggest ¦Ø -3 LCPUFAs may be effective in eating disorders. However, pharmacodynamic and pharmacokinetic considerations suggest a greater benefit from the combination of both components. Conclusion: The combination of a choline-containing molecule with an ¦Ø-3 LCPUFA may be clinically effective and well tolerated. This idea is supported by the current literature on the role of inflammation, the microbiome, the gut-brain-axis, hormonal, neurotransmitter and intracellular signalling, and on the structure and fluidity of nerve cells membranes in patients with AN
%K omega-3 fatty acids
%K choline
%K phosphatidylcholine
%K cytokines
%K anorexia nervosa
%U https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=344186