%0 Journal Article %T Glucagon-Like Peptide-1 Affects Taste Perception Differently in Women: a Randomized, Placebo-Controlled Crossover Study %A Altabas %A Velimir %A Bareti£¿ %A Maja %A Ku£¿ec %A Vesna %A Pavli£¿-Renar %A Ivana %A Uroi£¿ %A Valentina %J - %D 2019 %R 10.20471/acc.2019.58.02.06 %X Sa£¿etak Gastrointestinal tract is an important connector between food intake and body weight, it senses basic tastes in a similar manner as the tongue. The aim of the study was to find out how gut hormone glucagon-like peptide-1 (GLP-1) influences taste preference. Fourteen healthy participants (six male and eight female) were included in this double-blind, placebo-controlled crossover study. After overnight fast and salty fluid (oral sodium load), participants were randomized to receive placebo (500 mL of 0.9% saline) or GLP-1 infusion (1.5 pmol/kg/min) over a 3-hour period. At the end of infusion, participants chose food preferences from illustrations of food types representing 5 tastes. After 7 days, the protocol was repeated, this time those that had received placebo first got GLP-1 infusion, and those having received GLP-1 first got placebo. Change of taste preference after GLP-1 infusion but not after placebo was reported as response, and non-response was reported in case of taste persistence. A statistically significant difference in response type was found between genders, with women being more likely to change their taste preference after GLP-1 than men. The change of taste upon GLP-1 infusion observed in women might be ascribed to estrogen weight-lowering effects accomplished by receptor-mediated delivery %K Glucagon-like peptide 1 %K Taste %K Food preferences %K Cross-over studies %K Double-blind method %U https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=327156