%0 Journal Article
%T Clinical and Metabolic Effects of Alpha-Lipoic Acid Associated with Two Different Doses of Myo-Inositol in Women with Polycystic Ovary Syndrome
%A Benelli
%A Elena
%A Fidecicchi
%A Tiziana
%A Fruzzetti
%A Franca
%A Tonacchera
%A Massimo
%J -
%D 2020
%R https://doi.org/10.1155/2020/2901393
%X The aim of this retrospective study was to evaluate the effects of a treatment with ¦Á-lipoic acid (ALA) associated with two different doses of myo-inositol (MI) on clinical and metabolic features of women with polycystic ovary syndrome (PCOS). Eighty-eight women received the treatment, and 71 among them had complete clinical charts and were considered eligible for this study. All women were treated with 800£¿mg of ALA per day: 43 patients received 2000£¿mg of MI and 28 received 1000£¿mg of MI per day. Menstrual cyclicity, BMI, FSH, LH, estradiol, testosterone, androstenedione, fasting insulin, HOMA-IR, and insulin response to a 2£¿h OGTT£¿were evaluated before and after 6 months of treatment. The presence of diabetic relatives (DRs) was investigated. Cycle regularity was improved in 71.2% of women. The improvement of menstrual cyclicity occurred regardless of the state of IR and the presence of DRs of the patients. Women with IR mainly showed a significant improvement of metabolic parameters, while those without IR had significant changes of reproductive hormones. Patients with DRs did not show significant changes after the treatment. 85.7% of women taking 2000£¿mg of MI reported a higher improvement of menstrual regularity than those taking 1000£¿mg of MI (50%; ). In conclusion, ALA£¿+£¿MI positively affects the menstrual regularity of women with PCOS, regardless of their metabolic phenotype, with a more evident effect with a higher dose of MI. This effect seems to be insulin independent. The presence of IR seems to be a predictor of responsivity to the treatment in terms of an improvement of the metabolic profile
%U https://www.hindawi.com/journals/ije/2020/2901393/