%0 Journal Article
%T Prospective Multicenter Open-Label One-Arm Trial Investigating a Pumpkin Seed, Isoflavonoids, and Cranberry Mix in Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia: A Pilot Study
%A Chebel
%A Josselin Abi
%A El Helou
%A Elie
%A Mjaess
%A Georges
%A Nemr
%A Elie
%A Semaan
%A Albert
%J -
%D 2020
%R https://doi.org/10.1155/2020/6325490
%X Phytotherapy for lower urinary tract symptoms (LUTSs) due to benign prostate hyperplasia (BPH) is progressively demanded by patients and trusted by physicians. The aim was to assess the efficacy of a mix of pumpkin seed extract, soy germ isoflavonoids, and cranberry (Novexˋ) in the management of mild to moderate LUTS in BPH patients. Male patients aged ≡40 years, who had had mild to moderate LUTS for >6 months at screening, with no previous therapy or who are still symptomatic despite current use of alpha-blockers, were recruited. Exclusion criteria were an IPSS >19 and an age >80 years. The mixed compound was administered orally, daily, for 3 months. Patients were evaluated by means of IPSS, urological quality of life (uQoL) index, and International Index of Erectile Function (IIEF-5) at 3 visits: baseline (visit 1), 30 days (visit 2), and 90 days after treatment (visit 3). Among 163 screened patients, 128 patients (61.8ˋ㊣ˋ9.9 years) were recruited. IPSS improved from 15 (Q1ˋ:ˋ12每Q3ˋ:ˋ17) in visit 1, to 11 (Q1ˋ:ˋ8每Q3ˋ:ˋ14) in visit 2, and to 9 (Q1ˋ:ˋ6每Q3ˋ:ˋ12) in visit 3 ( ). uQoL improved from 4 (3每4) in visit 1, to 3 (2每3) in visit 2, and to 2 (1每2) in visit 3 ( ). The patients had an IIEF-5 score of 15 (12每18.7) in visit 1, 15 (12每18) in visit 2, and 17 (13每19) in visit 3 ( visits 1 vs. 2, visits 2 vs. 3, and visits 1 vs. 3). Treating mild to moderate LUTS/BPH patients with Novexˋ might therefore relieve symptoms, improve the quality of life, and have a mild beneficial effect on erectile function
%U https://www.hindawi.com/journals/au/2020/6325490/