%0 Journal Article
%T Pharmacokinetic Comparisons of Naringenin and Naringenin-Nicotinamide Cocrystal in Rats by LC-MS/MS
%A Jin
%A Bo
%A Ma
%A Chen
%A Xu
%A Dan
%A Zhang
%A Gui-Qiu
%A Zhang
%A Ting-Ting
%J -
%D 2020
%R https://doi.org/10.1155/2020/8364218
%X Naringenin (NAR), 4¡ä,5,7-trihydroxydihydroflavone, has a wide range of pharmacological activities but shows poor water solubility and low bioavailability. The pharmacokinetics and bioavailability of naringenin-nicotinamide cocrystal (NAR-NCT), which offers improved solubility, were evaluated in this study. Rats were orally administered NAR, a physical mixture of naringenin and nicotinamide (NAR£¿+£¿NCT), and NAR-NCT. The relative bioavailability of NAR-NCT was 175.09% of NAR, Cmax was 8.43 and 2.06 times of NAR and NAR£¿+£¿NCT, respectively, Tmax was advanced from 0.49£¿h to 0.09£¿h, CL was decreased from 91.1£¿L/h/kg to 49.1£¿L/h/kg, and t1/2 was increased from 5.37£¿h to 8.24£¿h, highlighting its rapid absorption and slow elimination. This study showed that NAR-NCT could improve the bioavailability of NAR
%U https://www.hindawi.com/journals/jamc/2020/8364218/