%0 Journal Article
%T Role of Secreted Frizzled-Related Protein 1 and Tumor Necrosis Factor-¦Á (TNF-¦Á) in Bone Loss of Patients with Rheumatoid Arthritis
%A Ginting
%A Andi Raga
%A Hidayat
%A Rudy
%A Koesnoe
%A Sukamto
%A Sumariyono
%A Sumariyono
%J -
%D 2020
%R https://doi.org/10.1155/2020/9149762
%X Bone loss is one of the emerging extra-articular manifestations of rheumatoid arthritis. TNF-¦Á is the main inflammatory cytokine that can directly increase bone resorption. However, its role in bone formation is still unknown, especially related to secreted frizzled-related protein 1 (SFRP-1), an osteoblast inhibitor. This study examines the correlation between TNF-¦Á and SFRP-1, with a bone turn over marker (CTX and P1NP). This is a cross-sectional study with 38 subjects of premenopausal female patients with RA. This study found that 60.6% of the patients were in remission or low disease activity. The median of TNF-¦Á was 10.6£¿pg/mL, mean of SFRP-1 was 9.29£¿ng/mL, mean of CTX was 2.74£¿ng/mL, and the median of P1NP was 34.04£¿pg/ml. There is positive correlation between TNF-¦Á and P1NP ( , ), also between SFRP-1 and P1NP ( ; ). A low level of TNF-£¿£¿, high level of SFRP-1, high level of CTX, and low level of P1NP in this study indicate a high bone turn over process, with dominant resorption activity in premenopausal female patients with RA
%U https://www.hindawi.com/journals/ijr/2020/9149762/