%0 Journal Article
%T The Ventilatory and Diffusion Dysfunctions in Obese Patients with and without Obstructive Sleep Apnea-Hypopnea Syndrome
%A Ben Saad
%A Helmi
%A Ghannouchi
%A Ines
%A Kammoun
%A Rim
%A Rouatbi
%A Sonia
%J -
%D 2020
%R https://doi.org/10.1155/2020/8075482
%X Objective. To analyze the ventilatory and alveolar-capillary diffusion dysfunctions in case of obesity with or without an OSAS. Methods. It is a cross-sectional study of 48 obese adults (23 OSAS and 25 controls). Anthropometric data (height, weight, and body mass index (BMI)) were collected. All adults responded to a medical questionnaire and underwent polysomnography or sleep polygraphy for apnea-hypopnea index (AHI) and percentage of desaturation measurements. The following lung function data were collected: pulmonary flows and volumes, lung transfer factor for carbon monoxide (DLCO), and fraction of exhaled nitric oxide (FeNO). Results. Obesity was confirmed for the two groups with a total sample mean value of BMI£¿=£¿35.06£¿¡À£¿4.68£¿kg/m2. A significant decrease in lung function was noted in patients with OSAS compared with controls. Indeed, when compared with the control group, the OSAS one had a severe restrictive ventilatory defect (total lung capacity: 93£¿¡À£¿14 vs. 79£¿¡À£¿12%), an abnormal DLCO (112£¿¡À£¿20 vs. 93£¿¡À£¿22%), and higher bronchial inflammation (18.40£¿¡À£¿9.20 vs. 31.30£¿¡À£¿13.60£¿ppb) ( ). Conclusion. Obesity when associated with OSAS increases the severity of pulmonary function and alveolar-capillary diffusion alteration. This can be explained in part by the alveolar inflammation
%U https://www.hindawi.com/journals/jobe/2020/8075482/