%0 Journal Article
%T Sodium Butyrate Protects N2a Cells against A¦Â Toxicity In Vitro
%A Fu
%A Shoupeng
%A Gong
%A Yuhong
%A Guo
%A Wenjin
%A Luan
%A Yongxin
%A Sun
%A Jingxuan
%A Wang
%A Wei
%A Wu
%A Yancheng
%A Yuan
%A Boyu
%J -
%D 2020
%R https://doi.org/10.1155/2020/7605160
%X Alzheimer¡¯s disease (AD) is a common neurodegenerative disease. A¦Â plays an important role in the pathogenesis of AD. Sodium butyrate (NaB) is a short-chain fatty acid salt that exerts neuroprotective effects such as anti-inflammatory, antioxidant, antiapoptotic, and cognitive improvement in central nervous system diseases. The aim of this study is to research the protective effects of NaB on neurons against A¦Â toxicity and to uncover the underlying mechanisms. The results showed that 2£¿mM NaB had a significant improvement effect on A¦Â-induced N2a cell injury, by increasing cell viability and reducing ROS to reduce injury. In addition, by acting on the GPR109A receptor, NaB regulates the expression of AD-related genes such as APP, NEP, and BDNF. Therefore, NaB protects N2a cells from A¦Â-induced cell damage through activating GPR109A, which provides an innovative idea for the treatment of AD
%U https://www.hindawi.com/journals/mi/2020/7605160/