%0 Journal Article
%T Elevated Lipoprotein-Associated Phospholipase A2 Independently Affects Age-Related Increases in Systolic Blood Pressure: A Nested Case-Control Study in a Prospective Korean Cohort
%A Kim
%A Minjoo
%A Lee
%A Jong Ho
%A Lee
%A Sang-Hyun
%A Yoo
%A Hye Jin
%J -
%D 2020
%R https://doi.org/10.1155/2020/5693271
%X Inflammatory markers are susceptible to changes over time. Thus, we observed changes in inflammatory markers correlating with age-related increases in blood pressure (BP) through a prospective study. The aim of this study was to investigate changes in inflammatory markers that correlate with age-related increases in BP. The study included 1,500 nondiabetic and normotensive healthy subjects at baseline. Of these, 121 individuals who developed hypertension (defined as systolic BP£¿¡Ý£¿140£¿mmHg or diastolic BP£¿¡Ý£¿90£¿mmHg) after 2 years formed the hypertension group. For each incident hypertension case, 2 age- and sex-matched control subjects were selected among those who did not develop hypertension (control group, n£¿=£¿242). After baseline adjustment, the hypertension group exhibited greater increases in body mass index (BMI), systolic and diastolic BP, triglyceride, total cholesterol, glucose, Lp-PLA2 activity, and urinary 8-epi-prostaglandin F2¦Á (8-epi-PGF2¦Á) levels compared to the control group. In the hypertension group, changes in (¦¤) systolic BP correlated positively with ¦¤ Lp-PLA2 activity, which correlated positively with ¦¤ low-density lipoprotein (LDL£¿) cholesterol and ¦¤ urinary 8-epi-PGF2¦Á levels. Moreover, multiple linear regression revealed baseline systolic BP and ¦¤ Lp-PLA2 activity to be independent predictors of ¦¤ systolic BP in the hypertension group. Our results suggest that age-related increases in systolic BP may correlate strongly with elevated Lp-PLA2 activity and that Lp-PLA2 can be considered a biomarker for systolic BP elevation
%U https://www.hindawi.com/journals/ijhy/2020/5693271/