%0 Journal Article
%T Analysis of Optimal Health-Related Quality of Life Measures in Patients Waitlisted for Lung Transplantation
%A Akiba
%A Miki
%A Aoyama
%A Akihiro
%A Chen-Yoshikawa
%A Toyofumi F
%A Chin
%A Kazuo
%A Date
%A Hiroshi
%A Hamaji
%A Masatsugu
%A Ikeda
%A Masaki
%A Isomi
%A Maki
%A Motoyama
%A Hideki
%A Nakajima
%A Daisuke
%A Oga
%A Toru
%A Okada
%A Yoshinori
%A Okawa
%A Tomoyo
%A Oto
%A Takahiro
%A Tokuno
%A Junko
%J -
%D 2020
%R https://doi.org/10.1155/2020/4912920
%X Background. Improving health-related quality of life (HRQL) is an important goal of lung transplantation, and St. George¡¯s Respiratory Questionnaire (SGRQ) is frequently used for assessing HRQL in patients waitlisted for lung transplantation. We hypothesized that chronic respiratory failure (CRF)-specific HRQL measures would be more suitable than the SGRQ, considering the underlying disease and its severity in these patients. Methods. We prospectively collected physiological and patient-reported data (HRQL, dyspnea, and psychological status) of 199 patients newly registered in the waiting list of lung transplantation. CRF-specific HRQL measures of the Maugeri Respiratory Failure Questionnaire (MRF) and Severe Respiratory Insufficiency Questionnaire (SRI) were assessed in addition to the SGRQ. Results. Compared to the MRF-26 and SRI, the score distribution of the SGRQ was skewed toward the worse ends of the scale. All domains of the MRF-26 and SRI were significantly correlated with the SGRQ. Multiple regression analyses to investigate factors predicting each HRQL score indicated that dyspnea and psychological status accounted for 12% to 28% of the variance more significantly than physiological measures did. The MRF-26 Total and SRI Summary significantly worsened from the baseline to 1 year ( and , respectively) in 103 patients who underwent a follow-up assessment without lung transplantation, while the SGRQ showed a marginal significant worsening ( ). Conclusions. The MRF-26 and SRI are valid, discriminative, and responsive in patients waitlisted for lung transplantation. In terms of the score distribution and responsiveness, CRF-specific measures may function better in their HRQL assessment than the currently used measures do
%U https://www.hindawi.com/journals/crj/2020/4912920/