%0 Journal Article
%T HSV-1 Encephalitis in an Elderly Man Receiving Ibrutinib for WaldenstromĄ¯s Macroglobulinemia
%A Wallace
%A Mark R.
%J -
%D 2020
%R https://doi.org/10.1155/2020/6516037
%X Ibrutinib is a major new addition to the therapeutic armamentarium for chronic lymphocytic leukemia, mantle cell lymphoma, WaldenstromĄ¯s macroglobulinemia, and chronic graft versus host disease. Though ibrutinib has proven to be a revolutionary new small molecule agent, and has relatively minimal toxicity as compared to traditional chemotherapy, infections have emerged as a major complication of therapy. While fungal infections have been the most problematic (including CNS aspergillosis), zoster, hepatitis B reactivation, and chronic hepatitis E have been reported in association with ibrutinib therapy. This report describes a case of herpes encephalitis in an 86-year-old WaldenstromĄ¯s patient receiving ibrutinib and speculates as to whether this late life encephalitis may have been related to ibrutinib
%U https://www.hindawi.com/journals/criid/2020/6516037/