%0 Journal Article %T Efficacy and Safety of Tracnil£¿ Administration in Patients with Dermatological Manifestations of PCOS: An Open-Label Single-Arm Study %A Anbu %A K. R. Radha %A Michael %A Margaret %A Ramanan %A Ezhil Arasan %A Ravi %A Sailatha %J - %D 2020 %R https://doi.org/10.1155/2020/7019126 %X Myo-inositol¡¯s role in improving acne by reducing hyperandrogenism has been demonstrated in PCOS patients. Inositol and associated molecules display inhibitory properties against 5-¦Á reductase, COX-2, and lipase enzymes in addition to their antimicrobial and anti-inflammatory properties. However, the role of myo-inositol is not well established in women patients with normal hormone levels but with clinical manifestations of PCOS. In this study, we evaluate the efficacy of Tracnil£¿, a combination of myo-inositol with folic acid and vitamin D3, in resolving acne in overweight women of menstruation age displaying normal hormone levels. It is a single-arm study conducted at 2 centers including 33 women with acne, hirsutism, and menstrual irregularities. Acne and hirsutism were assessed by manual lesion count, modified Cook¡¯s scale, and modified Ferriman¨CGallwey hirsutism score (mFGHS). Hormone levels and safety parameters were assessed throughout the study. Our results show that Tracnil£¿ monotherapy could drastically reduce acne-related lesions of both inflammatory and noninflammatory types as quickly as 8 weeks. Additionally, it improves hirsutism and menstrual irregularities. Adverse reactions were negligible during the whole study period with no drastic side effects reflected by a modulatory effect on hormone levels. Despite the subjects having normal hormone levels, the acne treatment with myo-inositol and vitamin D3 shows improvement in hirsutism and regularization of menstrual cycle. Therefore, we attribute the mechanism of action of Tracnil£¿ to modulation of receptor sensitivity to sex hormones or other downstream processing events. Tracnil£¿ may be considered as a first-line treatment for dermatological manifestations of PCOS even in the absence of significant hormonal abnormalities. This treatment is practically implementable in a dermatologists¡¯s office practise %U https://www.hindawi.com/journals/drp/2020/7019126/