%0 Journal Article
%T Successful Treatment of Crizotinib-Induced Fulminant Liver Failure: A Case Report and Review of Literature
%A Kothadia
%A Jiten P.
%A Kreitman
%A Kyle
%A Nair
%A Satheesh P.
%J -
%D 2020
%R https://doi.org/10.1155/2020/8247960
%X Crizotinib is a first-line tyrosine kinase inhibitor used for the treatment of metastatic lung cancer. Crizotinib-induced hepatotoxicity is a rare event. We report a case of a 46-year-old female with a history of metastatic lung cancer who presented with acute liver failure after being on crizotinib for two months. The medication was discontinued, and she was treated with N-acetylcysteine for seven days. Her liver function tests returned to normal limits after 26 days after admission. The precise mechanism and risk factors of crizotinib-induced hepatotoxicity remain unknown. Physicians should be aware of the potentially lethal side effect caused by crizotinib
%U https://www.hindawi.com/journals/crihep/2020/8247960/