%0 Journal Article
%T Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form
%A Ben Nacef
%A Ibtissem
%A Khiari
%A Karima
%A Mekni
%A Sabrine
%A Mhedhebi
%A Chedi
%A Nadia
%A Mchirgui
%A Riahi
%A Ines
%A Rojbi
%A Imen
%J -
%D 2020
%R https://doi.org/10.1155/2020/6284764
%X Langerhans cell histiocytosis (LCH) is a rare sporadic proliferative disorder of Langerhans cells. LCH rarely involves the thyroid gland. We report herein a case of a disseminated chronic form of LCH with a diagnosis established by histological examination of the thyroid gland. It is about a 37-year-old female who underwent total thyroidectomy for a thyroid nodule of the right lobe. Histological study showed a granulomatous thyroiditis, and the immunohistochemistry study revealed a strong positivity of histiocytes for the CD1 antigen and for the S100 protein. The incidence of LCH involving the thyroid gland, either as an isolated lesion or as a part of multisystemic disease, is extremely rare
%U https://www.hindawi.com/journals/crie/2020/6284764/