%0 Journal Article
%T Micro Particle Sizing Using Hilbert Transform Time Domain Signal Analysis Method in Self-Mixing Interferometry
%J Applied Sciences | An Open Access Journal from MDPI
%D 2019
%R https://doi.org/10.3390/app9245563
%X The present work envisages the development of a novel and low-cost self-mixing interferometry (SMI) technology-based single particle sensing system in a microchannel chip for real time single micro-scale particle sizing. We proposed a novel theoretical framework to describe the impulse SMI signal expression in the time domain induced by a flowing particle. Using Hilbert transform, the interferometric fringe number of the impulse SMI signal was retrieved precisely for particle size discrimination. For the ease of particle sensing, a hydrodynamic focusing microfluidic channel was employed by varying the flow rate ratio between the sample stream and the sheath liquid, and the particle stream of a controllable width was formed very easily. The experimental results presented good agreement with the theoretical values, providing a 300 nm resolution for the particle sizing measurement. View Full-Tex
%U https://www.mdpi.com/2076-3417/9/24/5563