%0 Journal Article
%T Piltunines A每F from the Marine-Derived Fungus Penicillium piltunense KMM 4668
%J Marine Drugs | An Open Access Journal from MDPI
%D 2019
%R https://doi.org/10.3390/md17110647
%X Six new carotane sesquiterpenoids piltunines A每F ( 1每 6) together with known compounds ( 7每 9) were isolated from the marine-derived fungus Penicillium piltunense KMM 4668. Their structures were established using spectroscopic methods. The absolute configurations of 1每 7 were determined based on circular dichroism (CD) and nuclear Overhauser spectroscopy (NOESY) data as well as biogenetic considerations. The cytotoxic activity of some of the isolated compounds and their effects on regulation of reactive oxygen species (ROS) and nitric oxide (NO) production in lipopolysaccharide-stimulated macrophages were examined. View Full-Tex
%U https://www.mdpi.com/1660-3397/17/11/647