%0 Journal Article
%T Histopathologic Findings in Canine Pituitary Glands
%A Andrea L. Vanderpool
%A Annie V. Chen
%A David S. Bruyette
%A Deidre M. DuSold
%A Hsin-Yi Weng
%A J. Catharine Scott-Moncrieff
%A Jos¨¦ A. Ramos-Vara
%A Linda G. Martin
%A Margaret A. Miller
%A Sina Jahan
%A Tina Jo Owen
%J Veterinary Pathology
%@ 1544-2217
%D 2018
%R 10.1177/0300985818766211
%X To optimize the histologic evaluation of hypophysectomy specimens, sections of 207 canine pituitary glands (196 postmortem, 11 hypophysectomy specimens) were reviewed. Adenohypophyseal proliferation was the most common (n = 79) lesion. Proliferative lesions were sparsely to densely granulated; the granules were usually basophilic to chromophobic and periodic acid-Schiff-positive. Adenohypophyseal proliferation was classified as hyperplasia (n = 40) if ¡Ü2 mm diameter with intact reticulin network, as microadenoma (n = 22) for 1¨C5 mm homogeneous nodules with lost reticulin network, or as macroadenoma (n = 17) for larger tumors. Craniopharyngeal duct cysts were common incidental lesions and the only lesion in 15 dogs. Uncommon diagnoses included lymphoma (n = 4), hemorrhagic necrosis (n = 4), metastatic carcinoma (n = 3), hypophysitis (n = 3), ependymoma (n = 2), craniopharyngioma (n = 2), and 1 case each of metastatic melanoma, pituicytoma, gliomatosis, germ cell tumor, meningioma, and atrophy. The pituitary histologic diagnosis was associated with hyperadrenocorticism (HAC; P < .001) and adrenocortical histologic diagnosis (P = .025). Both HAC and adrenocortical hyperplasia showed a positive trend with the degree of adenohypophyseal proliferation. The association of adrenocortical hyperplasia with HAC was not significant (P = .077). Dogs with adenohypophyseal proliferations were older than dogs with normal pituitary glands (P < .05). Brachycephalic breeds were overrepresented among dogs with pituitary macroadenoma or craniopharyngeal duct cysts, but the association was not statistically significant (P = .076). Adenohypophyseal hyperplasia was more common than adenoma among postmortem specimens, but was unexpected in >80% of cases. Pituitary macroadenoma was the most common diagnosis in hypophysectomy specimens
%K adenohypophyseal hyperplasia
%K dogs
%K hyperadrenocorticism
%K pituitary adenoma
%K pituitary-dependent hypercortisolism
%K transsphenoidal hypophysectomy
%U https://journals.sagepub.com/doi/full/10.1177/0300985818766211