%0 Journal Article
%T Effect of ¦Â
%A Farah Syed
%A Inderpal Soni
%A Neelu Kanwar Rajawat
%A PJ John
%A Rajbala Verma
%A Reena Mathur
%J Toxicology and Industrial Health
%@ 1477-0393
%D 2019
%R 10.1177/0748233719840957
%X The present study was planned to evaluate neurotoxic effects of ¦Â-cyfluthrin in female Swiss albino mice. Two doses of ¦Â-cyfluthrin, specifically, one-tenth of median lethal dose (LD50) and one-twentieth of LD50, were selected for the study. Open-field behaviour, exploratory behaviour and emotional status were affected, and animals showed anxiety-like behaviour after ¦Â-cyfluthrin administration. Spatial learning was decreased using the Hebb¨CWiliams maze. Acetylcholinesterase enzyme activity significantly decreased in the treated animals. The administration of ¦Â-cyfluthrin caused increased lipid peroxidation (malondialdehyde) and decreased superoxide dismutase, catalase and glutathione peroxidase activity in brain tissue. In conclusion, ¦Â-cyfluthrin caused neurotoxicity as well as oxidative damage in the brain of Swiss albino mice at the tested dose levels
%K ¦Â-Cyfluthrin
%K locomotory behaviour
%K neuromuscular coordination
%K learning
%K oxidative stress
%U https://journals.sagepub.com/doi/full/10.1177/0748233719840957