%0 Journal Article
%T 人血浆脂蛋白相关磷脂酶A2与冠心病的关系<br>The Relationship between Lipoprotein-Associated Phospholipase A2 and Coronary Heart Disease
%A 王林林
%A 陈作元
%A 张蕊
%A 田嘉伟
%A 吕晓冰
%A 辛辉
%J Advances in Clinical Medicine
%P 1229-1238
%@ 2161-8720
%D 2020
%I Hans Publishing
%R 10.12677/ACM.2020.107188
%X <div style=\"text-align:justify;\">
	目的：研究人血浆脂蛋白相关磷脂酶A2 (Lp-PLA2)与冠心病的关系。方法：选取2018年11月至2019年11月期间在青岛大学附属医院心血管内科住院的首次疑诊冠心病并行冠状动脉造影的患者共227例，以冠状动脉造影为金标准，将冠状动脉狭窄≥50%的患者作为冠心病组(160例)，将冠状动脉狭窄&lt;50%的患者作为对照组(67例)。冠心病组又分为单支病变组、双支病变组和三支病变组，同时采用Gensini评分将冠心病组患者分为低分组(≤20分)、中分组(20~≤40)、高分组(&gt;40分)。比较不同组间Lp-PLA2的差异。结果：1) 男性、吸烟、饮酒、血apoA水平降低、肌酐及Lp-PLA2水平是冠心病的危险因素；2) 不同病变支数分组间Lp-PLA2水平不同(P &lt; 0.05)，除单支与双支病变组比较外，各组间均有差异(P &lt; 0.05)；3) 多元回归分析显示：Lp-PLA2是冠心病的独立危险因素；饮酒和LDL是Lp-PLA2的主要相关因素。结论：1) Lp-PLA2是冠心病的独立危险因素且与冠心病严重程度呈正相关；2) 饮酒和LDL是Lp-PLA2的主要相关因素。<br />
Objective: To explore the relationship between lipoprotein-associated phospholipase A2. Methods: Selected the patients who were first suspected coronary atherosclerotic heart disease in the Department of Cardiology of the affiliated Hospital of Qingdao University from November 2018 to November 2019. Totally 227 patients were included in the study, with the standard that coronary artery stenosis ≥50% or not, the patients were divided into coronary artery disease group (160 cases) and control group (67 cases) according to coronary angiography. Besides, patients in coronary heart disease were divided into low score group (≤20), middle score group (20 - ≤40) and high score group (&gt;40) according to Gensini score to compare the level of Lp-PLA2 in different groups. Results: 1) Male, smoking, alcohol, decreased apoA, creatinine and Lp-PLA2 were risk factors for coronary heart disease. 2) The level of Lp-PLA2 was different among different groups (P &lt; 0.05), except single and double branches group; 3) Multiple regression analysis showed that Lp-PLA2 was an independent risk factor for coronary heart disease; drinking and LDL were major influencing factors for Lp-PLA2. Conclusion: 1) Lp-PLA2 is an independent risk factor for coronary heart disease and is positively correlated with the severity of coronary heart disease; 2) Drinking and LDL are main influencing factors for Lp-PLA2.
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%K 人血浆脂蛋白相关磷脂酶A2，冠状动脉粥样硬化性心脏病，Gensini评分<br>Lipoprotein-Associated Phospholipase A2 (Lp-PLA2)
%K Coronary Heart Disease (CAD)
%K Gensini Score
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=36420