%0 Journal Article
%T 双底物特异性酪氨酸磷酸化调节激酶1A及其抑制剂的研究进展<br>The Dual-Specificity Tyrosine Phosphorylation Regulated Kinase 1A and the Advances of Its Inhibitors
%A 王勇
%A 焦晓臻
%J Hans Journal of Medicinal Chemistry
%P 38-50
%@ 2331-8295
%D 2020
%I Hans Publishing
%R 10.12677/HJMCe.2020.82006
%X 双底物酪氨酸磷酸化调节激酶1A (Dual-specificity tyrosine phosphorylation-regulated kinase 1A, DYRK1A)是一种丝氨酸/苏氨酸蛋白激酶，作用底物广泛，参与人体内多种生理活动，与神经系统疾病、糖尿病、癌症等多种疾病相关，尤其被认为是神经系统退行性疾病的重要治疗靶点。本文介绍了DYRK1A的基因结构、生理功能、相关疾病及其抑制剂的研究进展。<br />
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), a kind of serine/threonine protein kinase, is able to phosphorylate numerous substrates, playing an important role in various physiological activities and correlates to multiple diseases including nervous system disease, cancer, diabetes and so on. In particular, it is considered as an important target of curing neurodegenerative diseases. This passage briefly introduces the genetic structure, physiological function, related diseases and the advances of the inhibitors of DYRK1A.
%K DYRK1A，抑制剂，神经退行性疾病<br>DYRK1A
%K Inhibitors
%K Neurodegenerative Diseases
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=35673