%0 Journal Article
%T 神经病理性疼痛形成的表观遗传学机制的研究进展<br>Research Progress on Epigenetic Mechanism of Neuropathic Pain
%A 马裴
%A 王德强
%A 范倩倩
%A 邵翠杰
%J Advances in Clinical Medicine
%P 1430-1436
%@ 2161-8720
%D 2020
%I Hans Publishing
%R 10.12677/ACM.2020.107215
%X <div style=\"text-align:justify;\">
	神经病理性疼痛(Neuropathic pain, NP)在2011年由IASP重新定义：由躯体感觉神经系统的损伤或疾病而直接造成的疼痛。其发病机制复杂目前尚未完全阐明，并且在临床上应用传统镇痛药物的治疗效果欠佳。NP给患者身体及心理上都带来巨大困扰，对医学领域也是一大挑战。近年来越来越多的研究证实表观遗传调控参与疼痛相关分子的转录及表达从而参与NP的形成和发展。本文主要从DNA甲基化、组蛋白乙酰化、非编码RNA三大表观遗传修饰方式参与神经病理性疼痛的产生机制进行综述。<br />
Neuropathic pain (NP) was redefined that pain was caused by injury or disease of the somatosensory nervous system directly by IASP in 2011. The pathogenesis of NP is so complicated that haven’t been illuminated. Otherwise, the effect of traditional analgesics is poor in clinical practice now. NP brings distress to patients’ physical and psychological, and is also a major challenge for the medical field. Recently, a lot of research has confirmed that epigenetic modifications participate in the induction and maintenance of NP by altering the transcription or expression of pain-related molecules. Our article introduces the generation mechanism of NP from the following Epigenetic modifications: DNA methylation, Histone acetylation and Non-conding RNA.
</div>
%K 神经病理性疼痛，表观遗传修饰，DNA甲基化，组蛋白乙酰化，非编码RNA<br>Neuropathic Pain
%K Epigenetic Modification
%K DNA Methylation
%K Histone Acetylation
%K Non-Conding RNA
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=36641