%0 Journal Article
%T 肝炎病毒对NF-&kappa;B信号通路的调控作用<br>Regulation of NF-Kappa B Signaling Pathway by Hepatitis Viruses
%A 王文静
%A 龚石林
%A 禹文海
%A 黄芬
%J Hans Journal of Biomedicine
%P 35-42
%@ 2161-8984
%D 2020
%I Hans Publishing
%R 10.12677/HJBM.2020.103006
%X <div style=\"text-align:justify;\">
	先天免疫应答是机体抵抗病毒感染的第一道防线。NF-κB信号通路作为先天免疫应答的重要部分，能够通过促进多种细胞因子产生而抵抗病原体的入侵。病毒可通过抑制NF-κB表达，逃逸宿主免疫反应，而有些病毒则可利用NF-κB的活化，促进自身的复制。肝炎病毒是引起病毒性肝炎的一大类病原体。目前，有关肝炎病毒对NF-κB信号通路的调控还没有系统的文献报道，本文将就乙型、丙型、丁型、戊型四种肝炎病毒对NF-κB信号通路的调控进行综述。<br />
The innate immune response is the first line of host against viral infection. As an important part of the innate immune response, NF-kappa B (NF-κB) signaling pathway can protect host against patho-gen invasion by activating the production of cytokines. Viruses can inhibit the expression of NF-κB by escaping the host immune response, while some viruses can use the activation of NF-κB to promote replication. Hepatitis viruses are the major pathogens of viral hepatitis. Up to now, there is no comprehensive report about the relationship between hepatitis viruses and NF-κB signaling pathway. The regulation of NF-κB signaling pathway during hepatitis viruses (B, C, D and E) infection was summered to clarify the interaction between NF-κB signaling pathway and hepatitis viruses.
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%K 肝炎病毒，NF-&kappa
%K B信号通路，先天免疫，免疫逃逸<br>Hepatitis Virus
%K NF-&kappa
%K B Signaling Pathway
%K Innate Immunity
%K Immune Escaping
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=36411