%0 Journal Article
%T 乙酰左旋肉碱的神经保护作用最新研究进展<br>The Latest Research Progress of the Neuroprotective Effect of Acetyl-L-Carnitine
%A 裴腾勃
%A 张梦洁
%A 杨彦玲
%J Advances in Clinical Medicine
%P 1678-1684
%@ 2161-8720
%D 2020
%I Hans Publishing
%R 10.12677/ACM.2020.108251
%X <div style=\"text-align:justify;\">
	乙酰左旋肉碱(Acetyl L-carnitine, ALC)是左旋肉碱(L-carnitine, LC)的主要乙酰酯，它在中间代谢中起重要作用，作为乙酰基的供体，促进脂肪酸在细胞质中从细胞质向线粒体的传递。ALC对线粒体的形态及功能有积极的保护作用；ALC还具有抗氧化和抗凋亡活性。此外，ALC对突触形态和突触传递均具有神经调节作用，这些效应是由于ALC通过调节中枢神经系统中多个靶点的基因表达而产生的。ALC在治疗各种病因的神经病变方面已显示出有效性和高耐受性，并且它在各种神经疾病，如疼痛性神经病变和抑郁症的临床应用中具有相当杰出的贡献。本综述主要阐述了ALC对神经系统影响的研究现状。<br />
Acetyl L-carnitine (ALC) is the main acetyl ester of L-carnitine (LC). It plays an important role in the intermediate metabolism. As the donor of acetyl group, it promotes the transfer of fatty acids from cytoplasm to mitochondria in the cytoplasm. ALC has a positive protective effect on the morphology and function of mitochondria, and also has antioxidant and anti-apoptosis activities. In addition, ALC has neuromodulation effects on synaptic morphology and synaptic transmission. These effects are caused by ALC regulating gene expression of multiple targets in the central nervous system. ALC has been shown to be effective and highly tolerable in the treatment of neuropathy of various causes, and it has made outstanding contributions to the clinical application of various neuropathy, such as painful neuropathy and depression. This review focuses on the current research status of the effects of ALC on the nervous system.
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%K 乙酰左旋肉碱，线粒体，神经调控，抗氧化<br>Acetyl-L-Carnitine
%K Mitochondria
%K Neuroregulation
%K Antioxidation
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=37103