%0 Journal Article
%T 双醋瑞因杂质的合成<br>Synthesis of Diacerein Impurities
%A 代泽琴
%A 张毅
%A 冯广卫
%J Hans Journal of Chemical Engineering and Technology
%P 362-366
%@ 2161-8852
%D 2020
%I Hans Publishing
%R 10.12677/HJCET.2020.105046
%X 本文以芦荟大黄素为起始原料，经氧化、乙酰化、保护、氢解四步反应合成了双醋瑞因杂质；该杂质的合成对仿制药的申报和质量研究有一定意义。其化合物经ESI-MS、IR、<sup>1</sup>H NMR、<sup>13</sup>C NMR元素分析确证。<br />
Using aloe emodin as the starting material, the diacerein impurities were synthesized by oxidation, acetylation, protection and hydrolyzation. The synthesis of the impurity is of certain significance to the application and quality research of generic drugs. The compounds were characterized by ESI-MS, IR, <sup>1</sup>H NMR, and <sup>13</sup>C NMR.
%K 杂质，分离纯化，合成<br>Impurity
%K Separation and Purification
%K Synthesis
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=37509