%0 Journal Article
%T 马兜铃酸类物质与肝癌关系的研究进展<br>The Relationship between Aristolochic Acids and Hepatocellular Carcinoma
%A 苏强
%A 马建波
%A 孙娜
%A 赵天宇
%A 陈侃
%A 张勇
%J Advances in Clinical Medicine
%P 1951-1959
%@ 2161-8720
%D 2020
%I Hans Publishing
%R 10.12677/ACM.2020.109293
%X <div style=\"text-align:justify;\">
	马兜铃酸类物质(aristolochic acids, AAs)是一类普遍存在于马兜铃属和细辛属植物中的硝基菲类有机酸化合物，因具有抗感染、抗癌、增强免疫、调节血压及终止妊娠等作用而广泛应用于中医治疗。但也有研究表明，长期服用含AAs的药物可导致多种系统疾病，如输尿管移行上皮细胞癌、结肠腺癌、乳腺癌浸润性导管癌等，关于AAs诱发各类疾病的机制研究已广泛展开。目前报道AAs暴露对肝脏毒性作用的实验研究尚较少，本文总结了AAs的化学结构和毒理作用机制，并阐述了其诱发肝细胞性肝癌(Hepatocellular carcinoma, HCC)的可能机制，期望为临床合理应用含AAs的药物提供参考。<br />
Aristolochic acid compound (aristolochic acids, AAs) is a kind of nitrophenanthrene organic acid compound commonly found in Aristolochia and Asarum plants. It is widely used in traditional Chinese medicine treatment for anti-infection, anti-cancer, enhanced immunity, regulation of blood pressure and termination of pregnancy. However, some studies showed that long-term use of the drugs containing AAs leads to a variety of diseases, such as transitional cell carcinoma of ureter, colonnade carcinoma, as well as invasive ductal carcinoma of breast. The mechanism of diseases induced by AAs has been widely explored. At present, the experimental study about the toxic effect of AAs on liver is few. This review summarized the chemical structure and toxicological mechanism of AAs, and also analyzed the possible mechanism of (Hepatocellular carcinoma, HCC) induced by AAs, in order to provide reference for the rational use of drugs containing AAs.
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%K 马兜铃酸，肝细胞性肝癌，毒理作用<br>Aristolochic Acid
%K Hepatocellular Carcinoma
%K Toxicological Effect
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=37593