%0 Journal Article
%T Colonic malignant peripheral nerve sheath tumour in a cat
%A Cheryl Sangster
%A Lara Boland
%A Laura Setyo
%A Laurencie Brunel
%A Peter Bennett
%A Timothy Foo
%J Journal of Feline Medicine and Surgery Open Reports
%@ 2055-1169
%D 2019
%R 10.1177/2055116919849979
%X A 14-year-old male neutered domestic mediumhair cat presented with a 4 month history of inappetence and weight loss. Pertinent abnormalities on haematology and biochemistry included a mild microcytic regenerative anaemia (packed cell volume [PCV] 24% [reference interval (RI) 30¨C45%], mean cell volume 30.8 fl [RI 40¨C45 fl], absolute reticulocyte count 326.8 ¡Á 1012) and increased alkaline phosphatase activity (76 IU/l; RI <50 IU/l). Abdominal ultrasound and CT scan revealed masses in the transverse colon (2.0 cm ¡Á 1.2 cm) and right medial liver lobe (5.0 cm diameter). Thoracic radiographs were unremarkable. Right medial liver lobe resection and colectomy were performed. Immunohistochemistry was positive for S-100 protein, vimentin and glial fibrillary acidic protein, very weakly positive for c-kit and negative for muscle-specific actin and CD18, consistent with a colonic malignant peripheral nerve sheath tumour (MPNST) with a hepatic metastasis. Postoperative treatment with metronomic cyclophosphamide was well tolerated. Eighteen months postoperatively the cat re-presented after 3 days of progressive lethargy and inappetence. Haematology revealed a marked non- or pre-regenerative anaemia (PCV 10%). Coagulation times were prolonged (prothrombin time 39 s [RI 15¨C22 s] and activated partial thromboplastin time >300 s [RI 65¨C119 s]). Abdominal ultrasound identified multiple renal and hepatic nodules. Euthanasia was performed and post-mortem examination confirmed metastasis of the MPNST. This report describes the treatment of a metastatic colonic peripheral nerve sheath tumour in a cat. Feline visceral MPNSTs are rare and little is known about prognosis or optimal treatment
%K Peripheral nerve sheath tumour
%K metastasis
%K metronomic chemotherapy
%K cyclophosphamide
%U https://journals.sagepub.com/doi/full/10.1177/2055116919849979