%0 Journal Article %T Combined Sclerosing and Spindle Cell Rhabdomyosarcoma in Previous Craniotomy Site: A Case Report and a Review of the Literature %A Arthur P. Staddon %A Elliott Lhospital %A Eric L. Zager %A Hongxing Gui %A John S. Brooks %A Paul J. L. Zhang %A Suneel N. Nagda %J International Journal of Surgical Pathology %@ 1940-2465 %D 2019 %R 10.1177/1066896918802030 %X Sclerosing rhabdomyosarcoma (RMS) is a rare subtype of RMS with unique prominent stromal hyalinization and a pseudovascular architecture. It overlaps morphologically with spindle cell RMS and poses both diagnostic and therapeutic challenges because of its rarity and aggressive clinical course. In this article, we report a case of sclerosing RMS arising from a prior craniotomy site, which demonstrated both sclerosing and spindle cell components. A literature review of RMS with sclerosing morphology identified 122 cases. Our review documents the following: sclerosing RMS occurs in both childhood and adult populations, has a predilection for the head and neck areas, and has a worse prognosis in adults. Sclerosing RMS harbors a high frequency of MYOD1 mutations, conferring a poor clinical outcome. Sclerosing RMS and spindle RMS likely represent a morphologic spectrum of one entity %K sclerosing rhabdomyosarcoma %K spindle cell rhabdomyosarcoma %K soft tissue %K stromal hyalinization %K pseudovascular %U https://journals.sagepub.com/doi/full/10.1177/1066896918802030