%0 Journal Article
%T Combined Sclerosing and Spindle Cell Rhabdomyosarcoma in Previous Craniotomy Site: A Case Report and a Review of the Literature
%A Arthur P. Staddon
%A Elliott Lhospital
%A Eric L. Zager
%A Hongxing Gui
%A John S. Brooks
%A Paul J. L. Zhang
%A Suneel N. Nagda
%J International Journal of Surgical Pathology
%@ 1940-2465
%D 2019
%R 10.1177/1066896918802030
%X Sclerosing rhabdomyosarcoma (RMS) is a rare subtype of RMS with unique prominent stromal hyalinization and a pseudovascular architecture. It overlaps morphologically with spindle cell RMS and poses both diagnostic and therapeutic challenges because of its rarity and aggressive clinical course. In this article, we report a case of sclerosing RMS arising from a prior craniotomy site, which demonstrated both sclerosing and spindle cell components. A literature review of RMS with sclerosing morphology identified 122 cases. Our review documents the following: sclerosing RMS occurs in both childhood and adult populations, has a predilection for the head and neck areas, and has a worse prognosis in adults. Sclerosing RMS harbors a high frequency of MYOD1 mutations, conferring a poor clinical outcome. Sclerosing RMS and spindle RMS likely represent a morphologic spectrum of one entity
%K sclerosing rhabdomyosarcoma
%K spindle cell rhabdomyosarcoma
%K soft tissue
%K stromal hyalinization
%K pseudovascular
%U https://journals.sagepub.com/doi/full/10.1177/1066896918802030