%0 Journal Article
%T A Patient
%A David Wang
%A Inga T. Lennes
%A J. Shannon Swan
%A Jennifer S. Temel
%A Karen Donelan
%A Lisa Keller
%A Natalie N. Stump
%J MDM Policy & Practice
%@ 2381-4683
%D 2018
%R 10.1177/2381468318801565
%X Background. A preference-based quality-of-life index for non每small cell lung cancer was developed with a subset of Functional Assessment of Cancer Therapy (FACT)每General (G) and FACT每Lung (L) items, based on clinician input and the literature. Design. A total of 236 non每small cell lung carcinoma patients contributed their preferences, randomly allocated among three survey groups to decrease burden. The FACT-L Utility Index (FACT-LUI) was constructed with two methods: 1) multiattribute utility theory (MAUT), where a visual analog scale (VAS)每based index was transformed to standard gamble (SG); and 2) an unweighted index, where items were summed, normalized to a 0 to 1.0 scale, and the result transformed to a scale length equivalent to the VAS or SG MAUT-based model on a Dead to Full Health scale. Agreement between patients＊ direct utility and the indexes for current health was assessed. Results. The agreement of the unweighted index with direct SG was superior to the MAUT-based index (intraclass correlation for absolute agreement: 0.60 v. 0.35; mean difference: 0.03 v. 0.19; and mean absolute difference 0.09 v. 0.21, respectively). Mountain plots showed substantial differences, with the unweighted index demonstrating a median bias of 0.02 versus the MAUT model at 0.2. There was a significant difference (P = 0.0002) between early (I-II) and late stage (III-IV) patients, the mean difference for both indexes being greater than distribution-based estimates of minimal important difference. Limitations. The population was limited to non每small cell lung cancer patients. However, most quality-of-life literature consulted and the FACT instruments do not differentiate between lung cancer cell types. Minorities were also limited in this sample. Conclusions. The FACT-LUI shows early evidence of validity for informing economic analysis of lung cancer treatments
%K quality of life
%K lung cancer
%K utilities
%U https://journals.sagepub.com/doi/full/10.1177/2381468318801565