%0 Journal Article
%T A Combined Use of Intravoxel Incoherent Motion MRI Parameters Can Differentiate Early
%A Hua Huang
%A Jason Chi Shun Leung
%A Min Deng
%A Pu-Xuan Lu
%A Weitian Chen
%A Y¨¢o T. Li
%A Y¨¬ Xi¨¢ng J. W¨¢ng
%J SLAS TECHNOLOGY: Translating Life Sciences Innovation
%@ 2472-6311
%D 2018
%R 10.1177/2472630317717049
%X This study investigated a combined use of intravoxel incoherent motion (IVIM) parameters, Dslow (D), PF (f), and Dfast (D*), for liver fibrosis evaluation. Sixteen healthy volunteers (F0) and 33 hepatitis-b patients (stage F1 = 15, stage F2¨C4 = 18) were included. With a 1.5 T MR scanner and respiration gating, IVIM diffusion-weighted imaging was acquired using a single-shot echo-planar imaging sequence with 10 b values of 10, 20, 40, 60, 80, 100, 150, 200, 400, and 800 s/mm2. Signal measurement was performed on right liver parenchyma. With a three-dimensional tool, Dslow, PF, and Dfast values were placed along the x axis, y axis, and z axis, and a plane was defined to separate healthy volunteers from patients. The three-dimensional tool demonstrated that healthy volunteers and all patients with liver fibrosis could be separated. Classification and regression tree showed that a combination of PF (PF < 12.55%), Dslow (Dslow < 1.152 ¡Á 10£¿3 mm2/s), and Dfast (Dfast < 13.36 ¡Á 10£¿3 mm2/s) could differentiate healthy subjects and all fibrotic livers (F1¨C4) with an area under the curve of logistic regression (AUC) of 0.986. The AUC for differentiation of healthy livers versus F2¨C4 livers was 1. PF offered the best diagnostic value, followed by Dslow; however, all three parameters of PF, Dslow, and Dfast contributed to liver fibrosis detection
%K magnetic resonance imaging (MRI)
%K intravoxel incoherent motion (IVIM)
%K diffusion
%K perfusion
%K liver
%K fibrosis
%U https://journals.sagepub.com/doi/full/10.1177/2472630317717049