%0 Journal Article
%T Short
%A Caiyan Li
%A Chun Wang
%A Jianfeng Wang
%A Jimian Yu
%A Wei Wang
%J Toxicology and Industrial Health
%@ 1477-0393
%D 2019
%R 10.1177/0748233718807303
%X The objective of this study was to investigate changes in intestinal histopathology and expression of heat-shock proteins (HSPs) in the small intestinal tissue of mouse after acute exposure to dibutyl phthalate (DBP). Forty-eight 60-day-old Institute of Cancer Research (ICR) mice were administered DBP by gavage once a day for 10 days. The mice were divided into three groups of 16 mice each: the high-dose group was administered 500 mg/kg body weight (BW) DBP; the low-dose group was administered 50 mg/kg BW; and the control group was not administered DBP. Significant increases in the uterine index, ovary index, and testicular index were observed in the DBP-exposed groups compared to those in the control group. Villus height and V/C ratio significantly increased (p < 0.05) in the duodenum and decreased (p < 0.05) in the jejunum after the administration of DBP. The goblet cell number decreased in both the duodenum and the jejunum of mice exposed to DBP (p < 0.05) compared to the number in the control group mice. Damage to the structure of the small intestine was accompanied by a marked increase in HSP27 expression and a decrease in the expression of HSP70 and HSP90 in both high-dose and low-dose groups. These results indicate that elevated HSP27 levels in the duodenum and jejunum may be important markers for acute DBP exposure and that HSP27 may act as a protective protein involved in intestinal mucosa repair
%K Dibutyl phthalate
%K intestinal tissues
%K heat-shock proteins
%K acute toxicity
%U https://journals.sagepub.com/doi/full/10.1177/0748233718807303