%0 Journal Article
%T The association between apelin polymorphisms and hypertension in China: A meta
%A Conghe Liu
%A Jun Ding
%A Lili Jia
%A Tianyi Wang
%J Journal of the Renin
%@ 1752-8976
%D 2019
%R 10.1177/1470320319827204
%X Apelin plays an important part in regulating blood pressure, metabolism, and the development of cancer. Recent studies have investigated the association of apelin polymorphisms and hypertension risk, but no meta-analysis has been conducted. Five studies were included in this meta-analysis in total. The pooled odds ratio and its corresponding 95% confidence interval were calculated by the random-effect model. The overall pooled odds ratio of the distribution of rs3761581 G allelic frequency was 0.90 (95% confidence interval: 0.82每1.00). In female participants, the pooled odds ratio of the frequency of G allele was 1.01 (95% confidence interval: 0.89每1.14). For males, the pooled odds ratio of the frequency of G allele was 0.69 (95% confidence interval: 0.46每1.03). As for rs56204867, the overall pooled odds ratio of the frequency of G allele was 1.09 (95% confidence interval: 0.86每1.37). In females, the pooled odds ratio of the frequencies of the G allele was 1.05 (95% confidence interval: 0.86每1.29). In male participants, the frequency of G allele did not show significant correlation with hypertension (pooled odds ratio=1.21 95% confidence interval: 0.81每1.79). This meta-analysis revealed that there was no correlation between apelin polymorphisms, rs3761581 and rs56204867, and the prevalence of hypertension
%K Apelin
%K essential hypertension
%K single nucleotide polymorphism
%K rs3761581
%K rs56204867
%K meta-analysis
%U https://journals.sagepub.com/doi/full/10.1177/1470320319827204