%0 Journal Article %T The association between apelin polymorphisms and hypertension in China: A meta %A Conghe Liu %A Jun Ding %A Lili Jia %A Tianyi Wang %J Journal of the Renin %@ 1752-8976 %D 2019 %R 10.1177/1470320319827204 %X Apelin plays an important part in regulating blood pressure, metabolism, and the development of cancer. Recent studies have investigated the association of apelin polymorphisms and hypertension risk, but no meta-analysis has been conducted. Five studies were included in this meta-analysis in total. The pooled odds ratio and its corresponding 95% confidence interval were calculated by the random-effect model. The overall pooled odds ratio of the distribution of rs3761581 G allelic frequency was 0.90 (95% confidence interval: 0.82每1.00). In female participants, the pooled odds ratio of the frequency of G allele was 1.01 (95% confidence interval: 0.89每1.14). For males, the pooled odds ratio of the frequency of G allele was 0.69 (95% confidence interval: 0.46每1.03). As for rs56204867, the overall pooled odds ratio of the frequency of G allele was 1.09 (95% confidence interval: 0.86每1.37). In females, the pooled odds ratio of the frequencies of the G allele was 1.05 (95% confidence interval: 0.86每1.29). In male participants, the frequency of G allele did not show significant correlation with hypertension (pooled odds ratio=1.21 95% confidence interval: 0.81每1.79). This meta-analysis revealed that there was no correlation between apelin polymorphisms, rs3761581 and rs56204867, and the prevalence of hypertension %K Apelin %K essential hypertension %K single nucleotide polymorphism %K rs3761581 %K rs56204867 %K meta-analysis %U https://journals.sagepub.com/doi/full/10.1177/1470320319827204