%0 Journal Article
%T Elevated preoperative serum levels of collagen I carboxyterminal telopeptide predict better outcome in early
%A Anniina Jˋˋskelˋinen
%A Arja Jukkola
%A Juha Risteli
%A Kirsi-Maria Haapasaari
%A Peeter Karihtala
%J Tumor Biology
%@ 1423-0380
%D 2019
%R 10.1177/1010428319847081
%X Type 1 collagen is an important part of the extracellular matrix and changes in its metabolism and distribution are essential in breast cancer induction and progression. Serum concentrations of type 1 collagen synthesis (aminoterminal propeptide (PINP)) and degradation markers (carboxyterminal telopeptide (ICTP)) have previously been studied in early and metastatic breast cancer, but no data are available on specific breast cancer subtypes. We assayed 662 preoperative serum samples for PINP and ICTP and 109 postoperative serum samples for ICTP. The results were linked to prospectively collected clinical data and the cases were divided into breast cancer subtypes for survival analyses. The concentrations of both pre- and postoperative ICTP serum levels increased linearly from ductal in situ carcinoma to stage I每II tumors, stage III tumors, and finally to those with concomitant primary metastases (preoperative ICTP, pˋ=ˋ0.009; postoperative ICTP, pˋ=ˋ0.016). High-preoperative ICTP levels were associated with better breast cancer-specific survival in connection with luminal-B-like (HER2-negative) tumors (pˋ=ˋ0.017), which was confirmed in Cox regression analysis (relative riskˋ=ˋ3.127; 95% confidence intervalˋ=ˋ1.081每9.049, pˋ=ˋ0.035), when T-class (relative riskˋ=ˋ4.049; 95% confidence intervalˋ=ˋ1.263每12.981; pˋ=ˋ0.019) and nodal status (relative riskˋ=ˋ3.896; 95% confidence intervalˋ=ˋ1.088每13.959; pˋ=ˋ0.037) were included in the analysis. In patients with triple-negative breast cancer, a high-preoperative ICTP level was a significant predictor of local relapse-free survival in univariate (pˋ=ˋ0.0020) and multivariate analyses (relative riskˋ=ˋ13.04; 95% confidence intervalˋ=ˋ1.354每125.5; pˋ=ˋ0.026; for T-class, relative riskˋ=ˋ2.128 and 95% confidence intervalˋ=ˋ0.297每15.23; pˋ=ˋ0.452; for N-class, relative riskˋ=ˋ0.332 and 95% confidence intervalˋ=ˋ0.033每3.307; pˋ=ˋ0.347). A preoperatively elevated serum ICTP level appears to be an important marker of better prognosis in triple-negative breast cancer and luminal-B-like (HER2-negative) subtypes
%K Breast cancer
%K breast cancer subtype
%K type 1 collagen
%K extracellular matrix
%K prognosis
%U https://journals.sagepub.com/doi/full/10.1177/1010428319847081