%0 Journal Article
%T Systemic Necrotizing Vasculitis in Sheep Is Associated With Ovine Herpesvirus 2
%A Akbar Dasjerdi
%A Anna LaRoca
%A Cristina W. Cunha
%A Hong Li
%A Ida L. Phillips
%A Julio Benavides Silv¨¢n
%A Kenneth Jackson
%A M. Carmen Ferreras
%A Mark Wessels
%A Patricia A. Pesavento
%A Rahul B. Dange
%A Santiago Diab
%A Valentin P¨¦rez
%J Veterinary Pathology
%@ 1544-2217
%D 2019
%R 10.1177/0300985818795166
%X Ovine herpesvirus 2 (OvHV-2) is one of the gammaherpesviruses in the genus Macavirus that can cause malignant catarrhal fever (MCF) in ungulates. Sheep are the adapted host for OvHV-2 and it is generally assumed that infection is not associated with disease in this species. However, cases of ¡°polyarteritis nodosa¡± or idiopathic systemic necrotizing vasculitis reported in sheep are similar to vascular lesions in clinically susceptible species with MCF. Using a recently developed in situ hybridization (ISH) method, we were able to identify OvHV-2 nucleic acids within lesions and correlate the viral distribution with systemic necrotizing vasculitis in 9 sheep, including both naturally and experimentally OvHV-2¨Cinfected animals. ISH, combined with polymerase chain reaction and histology, identify OvHV-2 as the likely agent responsible for sporadic, MCF-like vascular disease in sheep
%K arteritis
%K gammaherpesvirus
%K malignant catarrhal fever
%K ovine
%K ovine herpesvirus 2
%K polyarteritis nodosa
%K sheep
%K vasculitis
%U https://journals.sagepub.com/doi/full/10.1177/0300985818795166