%0 Journal Article
%T Urinary neutrophil gelatinase
%A Eman Abdelsameea
%A M. Ashraf Eljaky
%A Maha Elsabaawy
%A Nabil Omar
%A Soha Zaki El-shenawy
%A Tamer R Fouad
%J Tropical Doctor
%@ 1758-1133
%D 2019
%R 10.1177/0049475519830265
%X Cirrhotic patients with ascites are at high risk of developing spontaneous bacterial peritonitis (SBP). After exclusion of patients with acute kidney injury (AKI) or other infections, urinary neutrophil gelatinase-associated lipocalin (NGAL) levels were compared between two matched groups of Egyptian cirrhotic patients with ascites, mostly secondary to hepatitis C infection (98%). Group 1 had SBP (n£¿=£¿41) and group 2 did not (n£¿=£¿45). By univariate analysis, urinary-NGAL, high total bilirubin, serum creatinine, international normalised ratio and the Model of End-Stage Liver Disease (MELD) score and low platelet count were all significantly correlated with the presence of SBP, but only urinary-NGAL could independently predict development of SBP (P£¿=£¿0.001). Urinary-NGAL at a cut-off value of 1225£¿pg/mL, showed a sensitivity of 95% and a specificity of 76%, and is therefore a most useful tool
%K Lipocalin
%K cirrhosis
%K screening
%K ascites
%K peritonitis
%U https://journals.sagepub.com/doi/full/10.1177/0049475519830265