%0 Journal Article
%T Clinical¨Cpathological characteristics and short
%A Ana M Betancourt
%A Antonio Escobar
%A Antonio Rueda
%A Cristina Abitei
%A Francisco Rivas-Ruiz
%A Isabel Rodrigo
%A I£¿aki Zabalza
%A Jos¨¦Mar¨ªa Quintana
%A Juan Jos¨¦ Borrero Mart¨ªn
%A Marilina Garc¨ªa-Aranda
%A Mar¨ªa Manuela Morales Suarez-Varela
%A Matilde S¨¢nchez del Charco
%A Maximino Redondo
%A Rafael Cayetano Mart¨ªnez Garc¨ªa
%A Rafael F¨²nez
%A Raimundo Garc¨ªa del Moral
%A Teresa Pereda
%A Teresa T¨¦llez
%A null
%J Tumor Biology
%@ 1423-0380
%D 2019
%R 10.1177/1010428319835684
%X We investigate the clinical and pathological features related to variations in colorectal tumour apoptosis, proliferation and angiogenesis and the influence of the latter in short-term mortality (2£¿years); 551 tumour samples from a prospective cohort of patients with colorectal cancer were examined and tumour biology markers were determined as follows: percentage of apoptotic cells, by the terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling technique; Ki-67 antigen, as a cell proliferation marker and density of microvessels (as a marker of angiogenesis). An increase in the percentage of cellular apoptosis is significantly related to the presence of poorly differentiated tumours, with vascular invasion (p£¿<£¿0.001). The CD105 angiogenesis marker is not related to any clinical¨Cpathological parameter except that of higher frequency in older patients (p£¿=£¿0.03). Ki-67 is more frequently expressed in tumours with less nervous invasion (p£¿=£¿0.05). Neither apoptosis nor angiogenesis present any significant association with short-term survival. The only marker clearly related to 2-year survival is Ki-67, which is shown to be a good prognostic factor in the multivariate analysis (hazard ratio£¿=£¿0.49; 95% confidence interval£¿=£¿0.27¨C0.90). Therefore, in a prospective cohort of colorectal cancer patients, only Ki-67 is a marker of good prognosis in short-term follow-up
%K Cell proliferation
%K apoptosis
%K angiogenesis
%K colorectal neoplasms
%K Ki-67 marker
%U https://journals.sagepub.com/doi/full/10.1177/1010428319835684