%0 Journal Article
%T Physical activity, sedentary behaviour and risk of oesophago
%A Andrew D Spence
%A Andrew T Kunzmann
%A Chris R Cardwell
%A Helen G Coleman
%A Kristian P Mallon
%A Ruth F Hunter
%A ¨²na C McMenamin
%J United European Gastroenterology Journal
%@ 2050-6414
%D 2018
%R 10.1177/2050640618783558
%X Few observational studies have assessed the role of physical activity in oesophago-gastric cancer risk. This prospective cohort study aimed to assess the association between physical activity and risk of oesophageal or gastric cancer. A cohort of 359,033 adults aged 40¨C69 years were identified from the UK Biobank, which recruited participants between 2006 and 2010. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between self-reported levels of physical activity and screen-based sedentary behaviour and risk of oesophageal and gastric cancer were calculated using Cox proportional hazards models. During eight years of follow-up (mean£¿=£¿5.5), 294 oesophageal cancer and 217 gastric cancer cases were identified. Physical activity and screen-based sedentary behaviour levels were not associated with overall oesophago-gastric cancer risk. However, when compared with low levels, high physical activity levels were associated with a significantly reduced risk of gastric non-cardia cancer (HR 0.58, 95% CI 0.37¨C0.95). Moderate physical activity levels were associated with a 38% reduced risk of oesophageal adenocarcinoma (HR 0.62, 95% CI 0.43¨C0.89), although no dose-response association was apparent. Moderate, rather than high, physical activity levels were associated with the strongest reductions in oesophageal adenocarcinoma risk in this large UK prospective cohort
%K Oesophageal cancer
%K gastric cancer
%K adenocarcinoma
%K physical activity
%K sedentary behaviour
%U https://journals.sagepub.com/doi/full/10.1177/2050640618783558