%0 Journal Article
%T Performance changes of venous valves following tissue treatment with novel in vitro system
%A Garrett Easson
%A Hanna Jensen
%A Kevin Haney
%A Marc Girardot
%A Megan Laughlin
%A Morten Jensen
%J Phlebology
%@ 1758-1125
%D 2019
%R 10.1177/0268355518804360
%X The purpose of this study is to test venous valve performance and identify differences between native tissue and replacement devices developed with traditional tissue treatment methods using a new in vitro model with synchronized hemodynamic parameters and high-speed valve image acquisition. An in vitro model mimicking the venous circulation to test valve performance was developed using hydrostatic pressure driven flow. Fresh and glutaraldehyde-treated vein segments were placed in the setup and opening/closing of the valves was captured by a high-speed camera. Hemodynamic data were obtained using synchronized hardware and virtual instrumentation. Geometric orifice area and opening/closing time of the valves was evaluated at the same hemodynamic conditions. A reduction in geometric orifice area of 27.2 £¿¡À£¿14.8% (p£¿<£¿0.05) was observed following glutaraldehyde fixation. No significant difference in opening/closing time following chemical fixation was observed. The developed in vitro model was shown to be an effective method for measuring the performance of venous valves. The observed decrease in geometric orifice area following glutaraldehyde treatment indicates a decrease in flow through the valve, demonstrating the consequences of traditional tissue treatment methods
%K Prosthetic venous valve
%K venous system modeling
%K performance testing
%K chemical fixation
%K venous valve patency
%U https://journals.sagepub.com/doi/full/10.1177/0268355518804360