%0 Journal Article
%T The relationship between plasma renin activity and serum lipid profiles in patients with primary arterial hypertension
%A Artur Jurczyszyn
%A Danuta Czarnecka
%A Janusz K£¿kol
%A Katarzyna Wr¨®bel
%A Krystian Gruszka
%A Marek Rajzer
%A Marta Rojek
%A Ma£¿gorzata Wach-Pizo¨½
%A Tomasz Dro£¿d£¿
%A Tomasz Kameczura
%A Tomasz Pizo¨½
%A Wiktoria Wojciechowska
%J Journal of the Renin
%@ 1752-8976
%D 2018
%R 10.1177/1470320318810022
%X The aim of the study was to evaluate clinical and biochemical differences between patients with low-renin and high-renin primary arterial hypertension (AH), mainly in reference to serum lipids, and to identify factors determining lipid concentrations. In untreated patients with AH stage 1 we measured plasma renin activity (PRA) and subdivided the group into low-renin (PRA < 0.65 ng/mL/h) and high-renin (PRA £¿ 0.65 ng/mL/h) AH. We compared office and 24-h ambulatory blood pressure, serum aldosterone, lipids and selected biochemical parameters between subgroups. Factors determining lipid concentration in both subgroups were assessed in regression analysis. Patients with high-renin hypertension (N = 58) were characterized by higher heart rate (p = 0.04), lower serum sodium (p < 0.01) and aldosterone-to-renin ratio (p < 0.01), and significantly higher serum aldosterone (p = 0.03), albumin (p < 0.01), total protein (p < 0.01), total cholesterol (p = 0.01) and low-density lipoprotein cholesterol (LDL-C) (p = 0.04) than low-renin subjects (N = 39). In univariate linear regression, only PRA in the low-renin group was in a positive relationship with LDL-C (R2 = 0.15, ¦Â = 1.53 and p = 0.013); this association remained significant after adjustment for age, sex, and serum albumin and aldosterone concentrations. Higher serum levels of total and LDL-C characterized high-renin subjects, but the association between LDL-C level and PRA existed only in low-renin primary AH
%K Arterial hypertension
%K plasma renin activity
%K aldosterone-to-renin ratio
%K aldosterone
%K serum lipids
%U https://journals.sagepub.com/doi/full/10.1177/1470320318810022