%0 Journal Article
%T Primary Esophageal Mixed Sarcomatoid and Small Cell Neuroendocrine Carcinoma With Brain Metastasis: A Challenging Diagnosis on Biopsy
%A Antonio Galvao Neto
%A Christopher J. Schwartz
%A Esther Adler
%A Richard Hickman
%A Xuchen Zhang
%J International Journal of Surgical Pathology
%@ 1940-2465
%D 2019
%R 10.1177/1066896918782426
%X Mixed carcinomas in the esophagus are highly uncommon neoplasms that represent a diagnostic challenge on small tissue biopsies. We present a case of a primary mixed sarcomatoid¨Csmall cell carcinoma of the esophagus that was diagnosed after repeat sampling of the lesion. The components were morphologically distinct and could be further classified by immunohistochemistry. Next-generation sequencing identified mutations in PIK3CA and CDKN2A. The small cell component morphology was also identified in brain metastasis
%K esophagus
%K mixed tumor
%K small cell carcinoma
%K sarcomatoid carcinoma
%K brain metastasis
%U https://journals.sagepub.com/doi/full/10.1177/1066896918782426