%0 Journal Article
%T Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study
%A Abdullahi Hamisu Dambatta
%A Abiodun M. Adeoye
%A Adesola Ogunniyi
%A Albert Akpalu
%A Andrew Bock-Oruma
%A Arti Singh
%A Ayodipupo Oguntade
%A Benedict Calys-Tagoe
%A Bruce Ovbiagele
%A Carolyn Jenkins
%A Chidiebere Lucius Imoh
%A Dorcas Owusu
%A Emmanuel Sanya
%A Ezinne Melikam
%A Ezinne Uvere
%A Fred S Sarfo
%A Ganiyu Adeniyi Amusa
%A Godwin Ogbole
%A Godwin Osaigbovo
%A Gregory Fakunle
%A Innocent Chukwuonye
%A Isah Suleiman Yahaya
%A Joseph Yaria
%A Josephine Akpalu
%A Joshua Akinyemi
%A Kelechi Uwanruochi
%A Kolawole Wahab
%A Lambert Appiah
%A Lukman Owolabi
%A Luqman Ogunjimi
%A Matthew Onoja Akpa
%A Mayowa Owolabi
%A Mercy Faniyan
%A Michael Fawale
%A Morenikeji Komolafe
%A Mulugeta Gebreziabher
%A Nasir Abdulkadir Tabari
%A Odo Chidi Joseph
%A Oladimeji Adebayo
%A Olalekan Oyinloye
%A Olaleye Adeniji
%A Olumayowa Aridegbe
%A Osi Adeleye
%A Oyedunni Arulogun
%A Paul Olowoyo
%A Peter Olowoniyi
%A Philip Adebayo
%A Philip Kolo
%A Phillip Ibinaiye
%A Raelle Saulson
%A Reginald Obiako
%A Richard Efidi
%A Rufus O Akinyemi
%A Ruth Laryea
%A Sulaiman Lakoh
%A Taofeeq Sanni
%A Taofiki Sunmonu
%A Temitope Farombi
%A Tiwari Hemant
%A Vincent Shidali
%A Yahaya Obiabo
%J International Journal of Stroke
%@ 1747-4949
%D 2019
%R 10.1177/1747493018790059
%X It is crucial to assess genomic literacy related to stroke among Africans in preparation for the ethical, legal and societal implications of the genetic revolution which has begun in Africa. To assess the knowledge, attitudes and practices (KAP) of West Africans about stroke genetic studies. A comparative cross-sectional study was conducted among stroke patients and stroke-free controls recruited across 15 sites in Ghana and Nigeria. Participants' knowledge of heritability of stroke, willingness to undergo genetic testing and perception of the potential benefits of stroke genetic research were assessed using interviewer-administered questionnaire. Descriptive, frequency distribution and multiple regression analyses were performed. Only 49% of 2029 stroke patients and 57% of 2603 stroke-free individuals knew that stroke was a heritable disorder. Among those who knew, 90% were willing to undergo genetic testing. Knowledge of stroke heritability was associated with having at least post-secondary education (OR 1.51, 1.25每1.81) and a family history of stroke (OR 1.20, 1.03每1.39) while Islamic religion (OR=0.82, CI: 0.72每0.94), being currently unmarried (ORˋ=ˋ0.81, CI: 0.70每0.92), and alcohol use (ORˋ=ˋ0.78, CI: 0.67每0.91) were associated with lower odds of awareness of stroke as a heritable disorder. Willingness to undergo genetic testing for stroke was associated with having a family history of stroke (OR 1.34, 1.03每1.74) but inversely associated with a medical history of high blood pressure (ORˋ=ˋ0.79, 0.65每0.96). To further improve knowledge of stroke heritability and willingness to embrace genetic testing for stroke, individuals with less formal education, history of high blood pressure and no family history of stroke require targeted interventions
%K African
%K chronic disease
%K developing countries
%K genetic disorders
%K stroke
%K Sub-Saharan Africa
%U https://journals.sagepub.com/doi/full/10.1177/1747493018790059