%0 Journal Article
%T Preoperative Use of Statins in Carotid Artery Stenting: A Systematic Review and Meta
%A Anil K. Jonnalagadda
%A Damianos G. Kokkinidis
%A Ehrin J. Armstrong
%A Gregory G. Schwartz
%A Pascal Jabbour
%A Pavlos Texakalidis
%A Rohan V. Chitale
%A Stefanos Giannopoulos
%J Journal of Endovascular Therapy
%@ 1545-1550
%D 2018
%R 10.1177/1526602818794030
%X Purpose: To determine through meta-analysis whether administration of statins before carotid artery stenting (CAS) is associated with fewer periprocedural adverse events. Methods: All randomized and observational English-language studies of periprocedural statin administration prior to CAS that reported the outcomes of interest (stroke, transient ischemic attack, myocardial infarction, and death at 30 days) were included in a random-effects meta-analysis. The I2 statistic was used to assess heterogeneity. Meta-regression analysis was performed to determine whether an association of statin treatment with risk of outcome events was influenced by other trial-level baseline characteristics of statin-treated and untreated patients. Results: Eleven studies comprising 4088 patients were included. Patients who received statins prior to CAS had a significantly lower risk of stroke (OR 0.39, 95% CI 0.27 to 0.58, p<0.01; I2=0%) and death (OR 0.30, 95% CI 0.10 to 0.96, p=0.042; I2=0%). Statin use was not associated with a reduced risk of transient ischemic attack or myocardial infarction. In meta-regression analysis, other trial-level baseline characteristics had no significant influence on the association of statin treatment with death or stroke. Conclusion: Statin therapy prior to CAS is associated with decreased risk of perioperative stroke and death without any effect on the rates of transient ischemic attack or myocardial infarction
%K carotid stent/stenting
%K internal carotid artery
%K mortality
%K myocardial infarction
%K statins
%K stenosis
%K stroke
%K transient ischemic attack
%U https://journals.sagepub.com/doi/full/10.1177/1526602818794030