%0 Journal Article
%T Oligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome
%A Aksel Siva
%A Christine Lebrun
%A Clarisse Carra Dalli豕re
%A Daniel Pelletier
%A Daniel S Reich
%A Daniela Pohl
%A Darin T Okuda
%A David Brassat
%A Eugene D Shapiro
%A Evangeline Wassmer
%A Francoise Durand Dubief
%A Guillaume Mathey
%A J Nicholas Brenton
%A Jean Pelletier
%A Juan Ignacio Rojas
%A J谷rˋme de Seze
%A Mar Tintor谷
%A Matilde Inglese
%A Megan Langille
%A Naila Makhani
%A Orhun Kantarci
%A Patrick Vermersch
%A Philippe Cabre
%A Rinze F Neuteboom
%A Robert T Stone
%A Silvia Tenembaum
%A Sona Narula
%A Sunita Venkateswaren
%A Ugur Uygunoglu
%A Veronika Shabanova
%A Wendy Vargas
%A null
%J Multiple Sclerosis Journal
%@ 2055-2173
%D 2019
%R 10.1177/2055217319836664
%X Steps towards the development of diagnostic criteria are needed for children with the radiologically isolated syndrome to identify children at risk of clinical demyelination. To evaluate the 2005 and 2016 MAGNIMS magnetic resonance imaging criteria for dissemination in space for multiple sclerosis, both alone and with oligoclonal bands in cerebrospinal fluid added, as predictors of a first clinical event consistent with central nervous system demyelination in children with radiologically isolated syndrome. We analysed an international historical cohort of 61 children with radiologically isolated syndrome (≒18 years), defined using the 2010 magnetic resonance imaging dissemination in space criteria (Ped-RIS) who were followed longitudinally (mean 4.2ˋ㊣ˋ4.7 years). All index scans also met the 2017 magnetic resonance imaging dissemination in space criteria. Diagnostic indices (95% confidence intervals) for the 2005 dissemination in space criteria, with and without oligoclonal bands, were: sensitivity 66.7% (38.4每88.2%) versus 72.7% (49.8每89.3%); specificity 83.3% (58.6每96.4%) versus 53.9% (37.2每69.9%). For the 2016 MAGNIMS dissemination in space criteria diagnostic indices were: sensitivity 76.5% (50.1每93.2%) versus 100% (84.6每100%); specificity 72.7% (49.8每89.3%) versus 25.6% (13.0每42.1%). Oligoclonal bands increased the specificity of magnetic resonance imaging criteria in children with Ped-RIS. Clinicians should consider testing cerebrospinal fluid to improve diagnostic certainty. There is rationale to include cerebrospinal fluid analysis for biomarkers including oligoclonal bands in planned prospective studies to develop optimal diagnostic criteria for radiologically isolated syndrome in children
%K Radiologically isolated syndrome
%K multiple sclerosis
%K children
%U https://journals.sagepub.com/doi/full/10.1177/2055217319836664