%0 Journal Article
%T Predicting Factors for High
%A Antonino Ditto
%A Claudia Lombardo
%A Cono Scaffa
%A Domenica Lorusso
%A Fabio Martinelli
%A Francesca Taverna
%A Francesco Raspagliesi
%A Giorgio Bogani
%A Ilaria Sabatucci
%A Lavinia Mosca
%A Mauro Signorelli
%A Umberto Leone Roberti Maggiore
%A Valentina Chiappa
%J Reproductive Sciences
%@ 1933-7205
%D 2019
%R 10.1177/1933719118756747
%X To assess the risk of developing high-grade cervical dysplasia among women with low-grade cervical cytology and nonvisible squamocolumnar junction (SCJ) at colposcopic examination. Data of consecutive women with low-grade intraepithelial lesion(ˇÜLSIL) undergoing colposcopic examination, which was unsatisfactory (due to the lack of the visualization of the entire SCJ), were retrospectively reviewed. The risk of developing high-grade cervical intraepithelial neoplasia (CIN2+) was assessed using Kaplan-Meier and Cox models. Data of 86 women were retrieved. Mean (standard deviation [SD]) age was 36.3 (13.4) years. A total of 71 (82.5%) patients had high-risk human papillomavirus (HR-HPV) at the time of diagnosis. Among the 63 patients undergoing repetition of HPV testing, 15 (24%) and 48 (76%) women had positive and negative tests for HR-HPV at 12 months, respectively. We observed that 5 (33%) of 15 patients with HPV persistence developed CIN2+, while only 1 (2%) patient of 48 patients without HPV persistence developed CIN2+ (odds ratio [OR]: 23.5; 95% confidence interval [CI]: 2.46-223.7; P < .001). The length of HR-HPV persistence correlated with an increased risk of developing CIN2+ (P < .001; P for trend). High-risk HPV persistence is the only factor predicting for CIN2+ (hazard ratio: 3.19; 95% CI: 1.55-6.57; P = .002). High-risk HPV persistence predicts the risk of developing CIN2+ in patients with unsatisfactory colposcopic examination. Further studies are warranted in order to implement the use of HPV testing in patients with unsatisfactory colposcopy
%K HPV
%K high-grade dysplasia
%K unsatisfactory colposcopy
%K CIN
%U https://journals.sagepub.com/doi/full/10.1177/1933719118756747