%0 Journal Article %T Postoperative Complication Rates in 23 %A Andreas K. Lauer %A Austin D. Igelman %A Brock J. Alonzo %A Christina J. Flaxel %A Dongseok Choi %A John A. Johnson %A John P. Campbell %A Phoebe Lin %A Stanford C. Taylor %A Steven T. Bailey %A Thomas S. Hwang %J Journal of VitreoRetinal Diseases %@ 2474-1272 %D 2018 %R 10.1177/2474126418785824 %X The purpose of this study was to compare rates of clinically significant complications between 23- and 25-gauge pars plana vitrectomy (PPV) in vitreoretinal surgery. Demographics, PPV indication, and surgical complications were reviewed. Patients with prior PPV or other retina surgery; cases requiring silicone oil removal, keratoplasty, or glaucoma valve implant; patients <18 years old; or patients with <4 months of follow-up were excluded. Comparative and descriptive statistics were used to evaluate the data. A total of 579 eyes met inclusion criteria, and their charts were reviewed. Demographics, PPV indication, follow-up time, and lens status were similar (P > .05). A 23-gauge PPV was performed more frequently than a 25-gauge PPV (328 vs 251 eyes, respectively). Although rates of eyes with a clinically significant postoperative complication requiring surgical intervention were higher in 23-gauge PPV (112/325, 34.4%) than in 25-gauge PPV (54/250, 21.6%), PPVs indicated by rhegmatogenous retinal detachment were more common with 23-gauge PPVs (155/325, 47.7%) than with 25-gauge PPVs (37/250, 14.8%; P <.001) and were more likely to have postoperative complications; however, rates of recurrent retinal detachments were not different in the 2 cohorts (P = .862). When controlling for differences in indication, there was a moderately higher rate of postoperative complications following 23-gauge PPV (P = .063). This retrospective review suggests that clinically significant complications are moderately more likely following 23-gauge PPV compared with 25-gauge PPV, even when the differences in surgical indication are considered %K 23-gauge %K 25-gauge %K complications %K pars plana %K vitrectomy %U https://journals.sagepub.com/doi/full/10.1177/2474126418785824