%0 Journal Article
%T Analysis of Surface Levels of IL
%A Johannes Kornhuber
%A Johannes Weinbeer
%A Juan Manuel Maler
%A Martin Herrmann
%A Mateja Condic
%A Philipp Spitzer
%A Piotr Lewczuk
%A Timo Jan Oberstein
%J Journal of Geriatric Psychiatry and Neurology
%@ 1552-5708
%D 2019
%R 10.1177/0891988719841728
%X Increased concentrations of interleukin 1 (IL-1) in the cerebrospinal fluid and serum of patients with Alzheimer disease (AD) reduced phagocytic capacity point to an inflammatory activation of mononuclear phagocytes in AD. Interleukin 1 receptors (IL-1R) and the macrophage scavenger receptor I (MSRI) are important players in IL-1 signaling and phagocytosis. In 20 patients with AD and 17 controls, IL-1RI, IL-1RII, and MSRI were assessed on peripheral blood mononuclear cells by flow cytometry. IL-1¦Â, soluble IL-1 receptors, and IL-1R antagonist (IL-1Ra) were measured by enzyme-linked immunosorbent assay. The fraction of IL-1RI+ monocytes was increased by 10% and the expression of MSRI was reduced by 12% in AD. A 3.6% increased fraction of IL-1RI+ lymphocytes was accompanied by a 6.1% reduced expression of IL-1RII. The IL-1RI on monocytes and lymphocytes discriminated patients with AD with an accuracy of 0.79 and 0.75, respectively. The IL-1Ra was elevated in AD. Changes in the expression of IL-1 receptors and MSRI on peripheral blood cells fit to the concept of a proinflammatory state of the peripheral immune system. However, the observed differences are not strong enough to suggest their application as biomarkers for AD
%K Alzheimer disease
%K dementia
%K neurodegeneration
%K neuroinflammation
%K biomarker
%K IL-1RI
%K MSRI
%U https://journals.sagepub.com/doi/full/10.1177/0891988719841728