%0 Journal Article %T Dermatologically challenging syphilis presentation %A Alan R Katz %A Alan Y Komeya %A Douglas W Johnson %A Juval E Tomas %A Kozue Kobayashi %A Thomas S Namiki %J International Journal of STD & AIDS %@ 1758-1052 %D 2019 %R 10.1177/0956462418817636 %X An atypical early primary syphilis case presentation with multiple umbilicated papular lesions on the penis and a nonreactive syphilis serology was misdiagnosed as molluscum contagiosum. Over a period of eight weeks, prior to dermatologic consultation, the papules enlarged, ulcerated, and healed. New plaque and patch formation on the penis and scrotum led to a differential diagnosis of inverse psoriasis vs. syphilis. Histological examination of a shave biopsy specimen revealed numerous Treponema pallidum organisms and repeat syphilis serological test results confirmed a syphilis diagnosis. Lesions responded to treatment with benzathine penicillin. One must keep a high index of suspicion for syphilis in light of its diverse presentation and increasing incidence %K Syphilis %K chancre %K dermatology diagnosis %U https://journals.sagepub.com/doi/full/10.1177/0956462418817636