%0 Journal Article
%T Systemic delivery of MicroRNA mimics with polyethylenimine elevates pulmonary microRNA levels, but lacks pulmonary selectivity
%A Duncan J. Stewart
%A Kenny Schlosser
%A Mohamad Taha
%A Yupu Deng
%J Pulmonary Circulation
%@ 2045-8940
%D 2018
%R 10.1177/2045893217750613
%X Reversing pathologic alterations in vascular microRNA (miRNA) expression represents a potential therapeutic strategy for pulmonary hypertension. While polyethylenimine (PEI) has previously been shown to be an effective vehicle for vascular lung-directed delivery of plasmid DNA, it remains unclear whether this utility is generalizable to miRNAs. Here we show that despite elevated lung levels, the intravenous infusion of PEI¨CmiRNA mimic complexes fails to provide lung-selective delivery in rats
%K microRNA
%K pulmonary hypertension
%K lung delivery
%K polyethylenimine
%K mimic
%U https://journals.sagepub.com/doi/full/10.1177/2045893217750613