%0 Journal Article
%T Lethal fat embolism complicating Sotos syndrome
%A John D Gilbert
%A Roger W Byard
%J Medicine, Science and the Law
%@ 2042-1818
%D 2018
%R 10.1177/0025802418758210
%X Sotos syndrome is a rare congenital syndrome caused by deletions or mutations in the NSD1 gene (chromosome 5q35) which results in overgrowth. A wide range of manifestations may result in unexpected and/or early death, including congenital cardiac malformations and tumours, epilepsy, intra-tumoural haemorrhage or embolism and bleeding diatheses. A case of lethal pulmonary fat embolism complicating revision of a left total hip replacement following spontaneous fracture is reported in a 39-year-old man with Sotos syndrome. This case demonstrates that orthopaedic problems later in life may be added to potential causes of premature death in this syndrome
%K Sotos syndrome
%K sudden death
%K hip dislocation
%K fat embolism
%K spontaneous fracture
%K NSD1 gene
%U https://journals.sagepub.com/doi/full/10.1177/0025802418758210