%0 Journal Article
%T Metastatic Choriocarcinoma Masquerading as a Congenital Glabellar Hemangioma
%A Apurvi Patel
%A David Carpentieri
%A Harper Price
%A Kimberly Eisenstein
%A Nathan Page
%A Pooja Hingorani
%A Smita Bailey
%A Steve Taylor
%A Vanessa Gildenstern
%J Pediatric and Developmental Pathology
%@ 1615-5742
%D 2019
%R 10.1177/1093526618765039
%X Infantile choriocarcinoma (ICC) is a rare, highly malignant form of gestational trophoblastic neoplasia. Rapid diagnosis and initiation of treatment are paramount in reaching a successful outcome. Patients with these tumors typically present with a triad of anemia, hepatomegaly, and precocious puberty. Cutaneous manifestations of ICC are extraordinarily rare with few documented cases. Here, we describe a male neonate who presented to our Dermatology clinic with a rapidly growing, markedly vascular glabellar mass associated with abnormal laboratory values suggestive of Kasabach¨CMerritt phenomenon. The initial clinical impression of infantile hemangioma led to an initial treatment with propranolol. However, the mass continued to enlarge and a biopsy was obtained. Histology revealed a high-grade, poorly differentiated carcinoma. A robust immunohistochemical battery demonstrated tumor reactivity with Glut-1, GATA3, Glypican-3, CAM5.2, and ¦Â-hCG establishing the diagnosis of metastatic choriocarcinoma. The diagnosis was further supported by the elevated serum ¦Â-hCG. In addition to the glabellar mass, imaging demonstrated tumor foci in the liver and lung. Clinical investigation of the mother revealed no evidence of disease
%K clinical neonatology
%K dermatopathology
%K immunohistochemistry
%K liver
%K pediatric
%K placenta
%K soft tissue tumors
%K surgical pathology
%U https://journals.sagepub.com/doi/full/10.1177/1093526618765039