%0 Journal Article
%T The role of inflammation in the association between gestational diabetes and obstructive sleep apnea: A pilot study
%A G Bourjeily
%A M Carpenter
%A MH Bublitz
%A ML Okun
%A R Millman
%A S Amin
%A SM De La Monte
%J Obstetric Medicine
%@ 1753-4968
%D 2018
%R 10.1177/1753495X18780095
%X Obstructive sleep apnea is associated with pregnancy complications including gestational diabetes. Mechanisms underlying the association between obstructive sleep apnea and gestational diabetes remain to be elucidated. Twenty-three participants with gestational diabetes underwent home sleep apnea testing. Obstructive sleep apnea was defined as an apnea hypopnea index£¿>£¿5. Fasting morning blood samples were measured using multianalyte profiling (xMAP) multiplexed bead array immunoassay for Interleukin 6, tumor necrosis factor-alpha, and Interleukin 8. Age, body mass index, and gestational age at enrollment were 31£¿+£¿4.4 years, 35.7£¿+£¿7.4£¿kg/m2, and 28£¿¡À£¿4 weeks, respectively. Participants were 52% Caucasian and 16% had obstructive sleep apnea. We observed positive correlations between apnea hypopnea index and Interleukin 6 (r£¿=£¿0.62, p£¿=£¿0.005), Interleukin 8 (r£¿=£¿0.56, p£¿=£¿.56), and tumor necrosis factor-alpha (r£¿=£¿.58, p£¿=£¿.009). Women with obstructive sleep apnea had higher levels of Interleukin 6 (F£¿=£¿5.01, p£¿=£¿.037) and Interleukin 8 (F£¿=£¿6.33, p£¿=£¿.021) vs. women without obstructive sleep apnea. These preliminary results indicate that in women with gestational diabetes, apnea hypopnea index is associated with an elevated inflammatory profile
%K Obstructive sleep apnea
%K pregnancy
%K gestational diabetes
%K inflammation
%K sleep-disordered breathing
%U https://journals.sagepub.com/doi/full/10.1177/1753495X18780095